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Posted 29 May 2024

2 min read

The release is part of the ‘Djibouti Friendly Mosquito Programme’ to stop the spread of Anopheles stephensi

  • Anopheles stephensi is a mosquito species that is capable of transmitting both Plasmodium falciparum and P. vivax malaria parasites.
  • Only female mosquitoes bite and transmit malaria and other viral diseases.

Under the project, friendly non-biting male Anopheles stephensi mosquitoes have been developed and they carry self-limiting genes that kills female offspring before they reach maturity.

  • By reducing the female mosquito population, spread of the disease can be controlled.  

Technology involved in creating GM Mosquitoes

  • Laboratory Method: GM mosquitoes are mass-produced in a laboratory to carry two types of genes:
    • A self-limiting gene that prevents female mosquito offspring from surviving to adulthood.
      • Similar technology has been successfully used in India.
    •  A fluorescent marker gene that glows under a special red light. 
  • Gene Drives Technology (GDT): A type of genetic engineering technique that modifies genes so that they don’t follow the typical rules of heredity.
    • It increases the likelihood that a particular suite of genes will be passed onto the next generation, allowing the genes to rapidly spread through a population and override natural selection.

Key components of GDT

  • Gene to be spread
  • Cas9 enzyme that can cut DNA (acts as a molecular scissor)
  • Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), a prommable DNA sequence that identifies where the enzyme should cut.

 

  • Tags :
  • GM Mosquito
  • Gene Drives Technology
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